Epinephrine - As a result of probable for promethazine to reverse epinephrine’s vasopressor result, epinephrine should NOT be made use of to treat hypotension affiliated with promethazine overdose.
The diagnostic analysis of sufferers using this type of syndrome is difficult. In arriving at a analysis, it's important to identify conditions where the scientific presentation includes equally critical health care ailment (e.
Pediatric clients should be supervised to prevent potential harm in bicycle Driving or in other dangerous activities.
Impaired secretion from sweat glands following harmful doses of medicine with anticholinergic side effects could predispose to hyperthermia.
Steer clear of the usage of Promethazine HCl and Codeine Phosphate Oral Resolution in adolescents 12 to eighteen decades of age who produce other threat components that could raise their sensitivity to your respiratory depressant outcomes of codeine.
The mixture of promethazine hydrochloride and codeine phosphate should be applied with warning in pediatric affected person six years and older (see WARNINGS – Use in Pediatric Clients).
g., All those with evidence of increased intracranial force or Mind tumors), Promethazine HCl and Codeine Phosphate Oral Solution might lessen respiratory push, as well as resultant CO2 retention can additional improve intracranial strain. Additionally, opioids develop adverse reactions that will obscure the scientific study course of clients with head accidents.
Suggest patients to always use an precise milliliter measuring machine when measuring and administering Promethazine HCl and Codeine Phosphate Oral Solution. Tell patients that a family teaspoon will not be an correct measuring system and this kind of use could lead to overdosage and serious adverse reactions [see Overdosage (ten)].
Some medicines may have an affect on how promethazine performs or promethazine may possibly have an impact on how your other medicines get the job done. Know the medicines you're taking. Hold a listing of them with you to show your healthcare Experienced. Particularly tell your Health care Skilled if you are taking:
Promethazine HCl Oral Solution ought to be employed throughout pregnancy only if the opportunity advantage justifies the probable hazard on the fetus.
Propulsive peristaltic waves from the colon are decreased, even though tone can be improved to the point of spasm resulting in constipation. Other opioid-induced results may possibly include things like a discount in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
The opioid antagonists, naloxone and nalmefene, are particular antidotes for respiratory depression resulting from opioid overdose. For clinically substantial respiratory or circulatory depression secondary to codeine overdose, administer an opioid antagonist. An antagonist really should not be administered from the absence of clinically important respiratory melancholy. Because the period of opioid reversal is anticipated to become fewer than the length of action of codeine in Promethazine HCl and Codeine Phosphate Oral Alternative, meticulously check the patient right until spontaneous respiration is reliably reestablished.
The standard helpful dose of Promethazine HCl Oral Remedy for that Energetic therapy of nausea and vomiting in little ones or Grown ups is twenty five mg.
Stay clear of the use of Promethazine HCl and Codeine Phosphate Oral Option in adolescents twelve to 18 several years of age who produce other danger components that may enhance their sensitivity into the respiratory depressant effects of codeine. Chance factors contain ailments related to hypoventilation, such as postoperative status, obstructive click here sleep apnea, weight problems, critical pulmonary disease, neuromuscular illness, and concomitant use of other drugs that bring about respiratory despair.